3D tumor models
Human tumor architecture for stronger clinical relevance
3D modeling, using spheroids and organoids, is a critical tool for drug developers to assess drug activity using a format closer to the in vivo environment.
POAI uses spheroids with a high throughput testing approach in combination with our world-class biobank and active machine learning process. These patient-tumor derived spheroids represent a test matrix that preserves tumor stroma and correlates to our 2D platform with associated drug response data. Our spheroids are customizable to a tumor type of interest and when combined with our active machine learning/AI provide information relevant to 100’s of patient tumor samples.
Organoids are a separate, unique, approach to 3D modeling and are available to researchers who are also driven to understand how cancer therapeutics will behave in patients. Our organ-specific in vitro models are designed to better mimic the physiological environment of human tissue.
Mimics complex human organ environment
Our 3D tumor models recreate the complex human organ microenvironment to preserve critical interactions between a tumor and its surroundings—cellular and extracellular—in an organ- and disease-specific manner.
Preserves cellular composition
Our 3D tumor models support long-term survival and proliferation of malignant and non-malignant cellular components of tissues. This includes tumor cells, stroma and immune components.
Exhibits high correlation with clinical response
Cancer drug compounds tested in our models exhibit high correlation with clinical responses. Click here to view our white paper.
Fully customizable
Our tumor models are fully customizable to the tissue of interest. They are compatible with multiple cell types, drug classes—including small molecules, antibodies, antibody-drug conjugates, immunomodulatory agents, CAR-T cells, etc.—and downstream analysis methods.
Increasing relevance, improving outcomes
Drug candidate screening
Identification
of new drug
combinations
Rescue failed
drug candidates
Evaluation
of off-target
toxicity
Target discovery
Biomarker discovery
What can 3D tumor models do for you?
Talk to us about 3D tumor models today.
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Enable more efficient drug repurposing
Our spheroids can be combined with our active machine learning / AI platform to greatly expand the number of patient samples and drug responses explored.
Customize models
Additions to our organoid modeling approach can include immune components, CAFs and trans-well inserts, which allow flexibility to match your testing requirements.
3D tumor model resources
In this webinar we summarize the current state of 3D culture technologies and highlight relevant applications of each platform. Human cells have been grown in culture since the 1950s. However,...Learn more
In this webinar we will discuss how 3D cell culture overcomes the limitations of traditional 2D culture when it comes to predicting the therapeutic potential of pharmaceutical compounds in development....Learn more
In this webinar we discuss our 3D disease models and their use in drug development emphasizing the capacity of our patient-derived platform to mimic the native architecture of human tissues...Learn more
JOINT WEBINAR WITH LABCORP DRUG DEVELOPMENT In this webinar we will discuss the advantages of a 3D culture approach over the traditional methods, with particular emphasis on the importance of...Learn more
The high rates of clinical failure of new anticancer drugs highlight that the standard approaches to evaluate drug efficacy do not faithfully reproduce human biology, and thus, do not accurately...Learn more