3D tumor models
3D modeling is a critical tool for drug developers to assess drug activity using a format closer to the in vivo environment.
Predictive Oncology uses spheroids with a high throughput testing approach in combination with our world-class biobank and active machine learning process. These patient-tumor derived spheroids represent a test matrix that preserves tumor stroma and correlates to our 2D platform with associated drug response data. Our spheroids are customizable to a tumor type of interest and when combined with our active machine learning/AI provide information relevant to 100’s of patient tumor samples.
Our Multiple Myeloma Organoid system is a separate, unique, approach to 3D modeling and is available to researchers who are also driven to understand how cancer therapeutics will behave in patients. This in vitro model is designed to better mimic the physiological environment of human tissue.
Mimics complex human organ environment
Our 3D tumor models recreate the complex human organ microenvironment to preserve critical interactions between a tumor and its surroundings—cellular and extracellular—in an organ- and disease-specific manner.
Preserves cellular composition
Our 3D tumor models support long-term survival and proliferation of malignant and non-malignant cellular components of tissues. This includes tumor cells, stroma and immune components.
Exhibits high correlation with clinical response
Cancer drug compounds tested in our models exhibit high correlation with clinical responses. Click here to view our white paper.
Fully customizable
Our tumor models are fully customizable to the tissue of interest. They are compatible with multiple cell types, drug classes—including small molecules, antibodies, antibody-drug conjugates, immunomodulatory agents, CAR-T cells, etc.—and downstream analysis methods.
Increasing relevance, improving outcomes
Even when anticancer drugs demonstrate high efficacy in cell culture and animal models during early discovery, over 95% ultimately fail during clinical trials. Our patient-derived 3D spheroids and our organ specific organoid models aim to change that – enabling drug developers to test drug candidates within the native microenvironment of human tissues.
Drug candidate screening
Identification
of new drug
combinations
Rescue failed
drug candidates
Evaluation
of off-target
toxicity
Target discovery
Biomarker discovery
What can 3D tumor models do for you?
Enable more efficient drug repurposing
Our spheroids can be combined with our active machine learning / AI platform to greatly expand the number of patient samples and drug responses explored.
Customize models
Additions to our organoid modeling approach can include immune components, CAFs and trans-well inserts, which allow flexibility to match your testing requirements.
Talk to us about 3D tumor models today.
Complete the form and we’ll be in touch to discuss customized solutions for your needs.