Available models
Patient-derived 3D tumor models for a stronger correlation to clinical response
Our unique multi-component organ-specific extracellular matrix (ECM) enables accurate reconstruction of human tissue architecture driving a more accurate prediction of clinical outcomes. Models are compatible with all standard readout methods: flow cytometry, RNAseq, in situ imaging, high content imaging, CellTiter Glo, MTS and other readouts in your workflow.
Our organ-specific 3D culture models.
Scroll to browse our models, or get in contact to learn more. You can also browse frequently asked questions here.
Spheroid models
Get spheroid models for cancer cell lines from solid tumors and hematological malignancies. Cells cultured in 3D are embedded in our proprietary organ-specific ECM to provide a far more accurate readout of the drug response compared to conventional cell culture models.
Available models:
- Breast
- Lung
- Stomach
- Multiple myeloma
- AML
- Pancreas
Co-culture/multi-compartment
Get co-cultures of tumor epithelium with stroma and immune components. Our organ-specific 3D models incorporate epithelial spheroids formed by cancer cell lines, primary cancer-associated fibroblasts (CAFs) or primary non-malignant stroma, with or without immune lymphoid/myeloid immune cells.
The Reconstructed Metastasis (r-Met) model is a multi-compartment system enabling fractionation of tumor cells into primary, invasive and metastatic cell populations. This is the only available model that provides access to the metastatic cells for target discovery and drug testing.
Available models:
- AML
- Multiple myeloma
- Breast
- Lung
- Pancreas
- Stomach
Primary cells
Our patient-derived models utilize primary tumor cells grown in 3D in organ-specific ECM with disease-specific medium supplements. The resulting reconstructed tumor microenvironment provides a physiologically relevant platform to assess the efficacy and toxicity of anti-cancer agents. These models demonstrate high correlation with clinical response—enabling elimination of ineffective compounds early in the drug development process.
Available models:
- AML
- Multiple myeloma
Custom models
Our team of expert scientists is ready to create custom models for any tissue of interest. Please contact us below for details.
Talk to us about 3D tumor models today.
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3D tumor model resources
In this webinar we summarize the current state of 3D culture technologies and highlight relevant applications of each platform. Human cells have been grown in culture since the 1950s. However,...
In this webinar we will discuss how 3D cell culture overcomes the limitations of traditional 2D culture when it comes to predicting the therapeutic potential of pharmaceutical compounds in development....
In this webinar we discuss our 3D disease models and their use in drug development emphasizing the capacity of our patient-derived platform to mimic the native architecture of human tissues...
JOINT WEBINAR WITH LABCORP DRUG DEVELOPMENT In this webinar we will discuss the advantages of a 3D culture approach over the traditional methods, with particular emphasis on the importance of...
The high rates of clinical failure of new anticancer drugs highlight that the standard approaches to evaluate drug efficacy do not faithfully reproduce human biology, and thus, do not accurately...
